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This system involved the administration of anabolic steroids on rats, either orally or by injection (depending on the anabolic steroid being assessed)at times varying from days to 1 week after the start of the study. Because some rats were not administered a testosterone gel during the testosterone administration (and thus may not have had an opportunity to respond to anabolic steroids ) it was not possible to estimate the number of injections per day by a double blind comparison of the body weight of the animals and the number of injected rats. A 2 year follow up study indicated that, when there were differences between the groups, a small percentage of testosterone gel-naïve animals (8.9%) gained more weight compared to the control group (11.4%). As shown in Figure 2 of , it is clear that not all animals were adequately prepared for anabolic steroids administration. At the end of the 2 year study, a slight but noticeable decrease was recorded in the total body weight of the animals (3.2% for the testosterone group compared with 5.3% for the control group) and an increased mean body weight (2.3 kg for the testosterone group compared with 1.9 kg for the control group). The mean daily testosterone concentration was also reduced from 8.2 udl/24 h for the testosterone group to 6.1 udl/24h (3.8% increase). The treatment with high-doses of testosterone significantly reduced serum estradiol concentrations, particularly during the second month after the first injection (Figure 2b). At the end of the 2 year study, a significant increase in serum estradiol levels was observed in the testosterone group (Figure 3). Figure 3 The mean testosterone concentration at the end of the follow up study in the testosterone-treated animals. Data are shown as the mean ± S.E.M Conclusions In conclusion, these results indicate that high dose testosterone administration (3.8 mg/kg daily for 6 months) is not beneficial in obese, young males, despite the use of high doses of testosterone as indicated previously. As a result, such administration, together with treatment with high-dose testosterone gel does not seem to be beneficial if it involves a higher dose, and especially if combined with treatment with a gel to minimize the risk that the high-dose testosterone will be metabolized in the liver and increase triglyceride levels. It appears that testosterone gel, either in the form injected or orally, can produce more pronounced effects than testosterone injections alone. However, the benefit is far from 100% as the effects of testosterone gel in this study were limited to the treatment Related Article: